Comparison of the Effect of VaginalZataria multifloraCream and Oral Metronidazole Pill on Results of Treatments for Vaginal Infections including Trichomoniasis and Bacterial Vaginosis in Women of Reproductive Age

Abstract

Effect ofZataria multifloraon bacterial vaginosis andTrichomonas vaginalisis shown in vivo and in vitro. We compare the effectiveness ofZataria multifloracream and oral metronidazole pill on results of treatment for vaginal infections includingTrichomonasand bacterial vaginosis; these infections occur simultaneously. The study included 420 women with bacterial vaginosis,Trichomonas vaginalis, or both infections together, who were randomly divided into six groups. Criteria for diagnosis were wet smear and Gram stain. VaginalZataria multifloracream and placebo pill were administered to the experiment groups; the control group received oral metronidazole pill and vaginal placebo cream. Comparison of the clinical symptoms showed no significant difference in all three vaginitis groups receiving metronidazole pill and vaginalZataria multifloracream. However, comparison of the wet smear test results was significant in patients with trichomoniasis and bacterial vaginosis associated with trichomoniasis in the two treatment groups (p=0.001andp=0.01). VaginalZataria multifloracream had the same effect of oral metronidazole tablets in improving clinical symptoms of all three vaginitis groups, as well as the treatment for bacterial vaginosis. It can be used as a drug for treatment of bacterial vaginosis and elimination of clinical symptoms ofTrichomonasvaginitis.