Functional Polymorphisms inCOX-2Gene Are Correlated with the Risk of Oral Cancer

Abstract

Background. This meta-analysis investigated the association between functionalCOX-2gene polymorphisms and the risk of oral cancer.Methods. Several electronic databases were searched for published studies using combinations of keywords related toCOX-2gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software.Results. We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism inCOX-2showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained withCOX-2gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism inCOX-2did not confer susceptibility to oral cancers.Conclusion. Based on our results,COX-2gene polymorphisms, +837 T > C (rs5275) and −765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.