Affiliation:
1. Departament de Química Inorgànica, Avgda Diagonal, 647, Barcelona E-08028, Spain
2. Departament de Microbiología, Universitat de Barcelona, Avgda Diagonal, 645, Barcelona E-08028, Spain
Abstract
The complex [Pt2Cl2(Spym)4], where Spym = 2-mercaptopyrimidine, was synthesized and
analyzed spectroscopically. The presence in the P195t NMR spectrum, of only one signal for the Pt(III) indicates the symmetrical arrangement of the ligands and the identical setting of N, S and Cl atoms, PtS2ClN2, for the two Pt atoms being different to other compounds described in the
literature. The interaction of this complex with DNA was studied by several techniques, including circular dichroism, melting temperature determination, electron microscopy (EM) and atomic force
microscopy (TMAFM). Preliminary results show a high activity against HL-60 and HeLa tumour lines for the Pt-2-mercaptopyrimidine complex in comparison with cisplatin activity. Higher values for IC50 were obtained, while the values of LD50 were lower than those for cisplatin.
Subject
Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology
Cited by
44 articles.
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