Rh2(CF3CONH)4: The First Biological Assays of a Rhodium (II) Amidate-Reference-Cited by-同舟云学术

Rh2(CF3CONH)4: The First Biological Assays of a Rhodium (II) Amidate

Published:1997-01-01 Issue:6 Volume:4 Page:333-338
ISSN:0793-0291
Container-title:Metal-Based Drugs
language:en
Short-container-title:Metal-Based Drugs

Author:

Espósito Breno Pannia¹,Zyngier Szulim Ber²,de Souza Aparecido Ribeiro³,Najjar Renato¹

Affiliation:

1. Institute of Chemistry, University of São Paulo, Av. Lineu Prestes 748, São Paulo 05508-900, Brazil

2. Institute of Biomedical Sciences - I, University of São Paulo, Av. Lineu Prestes 1524, São Paulo 05508-900, Brazil

3. Institute of Chemistry, Federal University of Goiás, Campus II, P.O. Box 131, Goiânia 74001-970, Brazil

Abstract

The rhodium (II) complexes Rh2(tfa)4.2(tfac) and Rh2(tfacam)4 (tfacam = CF3CONH-,tfa = CF3COO-,tfac = CF3CONH2) were synthesized and characterized by microanalysis and electronic and vibrational spectroscopies. Rh2(tfacam)4 was tested both in vitro (U937 and K562 human leukemia cells and Ehrlich ascitic tumor cells) and in vivo for cytostatic activity and lethal dose determination, respectively. This is the first rhodium tetra-amidate to have its biological activity evaluated. The LD50 value for Rh2(tfacam)4 is of the same order as that of cisplatin, and it was verified that the rhodium complex usually needs lower doses than cisplatin to promote the same inhibitory effects.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology

Link

http://downloads.hindawi.com/archive/1997/715016.pdf

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. 1,3-N,O-Complexes of late transition metals. Ligands with flexible bonding modes and reaction profiles;Chemical Society Reviews;2017

2. Study of dinuclear Rh(II) complexes of phenylalanine derivatives as potential anticancer agents by using X-ray fluorescence and X-ray absorption;Microchemical Journal;2015-05

3. Amidate-Ligated Complexes of Rhodium(I): A Showcase of Coordination Flexibility;Organometallics;2015-04-01

4. Confocal Fluorescence Microscopy Studies of a Fluorophore-Labeled Dirhodium Compound: Visualizing Metal–Metal Bonded Molecules in Lung Cancer (A549) Cells;Journal of the American Chemical Society;2014-05-22

5. Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh2(μ-L)(HNOCCF3)3 where L= [OOCCH3]−, [OOCCF3]−, or [HNOCCF3]−;Inorganic Chemistry;2011-03-23