Complexes With Biologically Active Ligands. Part 91 Metal Complexes of 5-Benzoylamino- and 5-(3-Nitrobenzoyl-Amino)-1,3,4-Thiadiazole-2-Sulfonamide as Carbonic Anhydrase Inhibitors-Reference-Cited by-同舟云学术

Complexes With Biologically Active Ligands. Part 91 Metal Complexes of 5-Benzoylamino- and 5-(3-Nitrobenzoyl-Amino)-1,3,4-Thiadiazole-2-Sulfonamide as Carbonic Anhydrase Inhibitors

Published:1997-01-01 Issue:1 Volume:4 Page:1-7
ISSN:0793-0291
Container-title:Metal-Based Drugs
language:en
Short-container-title:Metal-Based Drugs

Author:

Jitianu Andrei¹²,llies Marc A.²,Briganti Fabrizio³,Scozzafava Andrea³,Supuran Claudiu T.³

Affiliation:

1. “I.G. Murgulescu” Institute of Physical Chemistry, Spl. Independentei, 202, Bucharest R-77208, Romania

2. University of Bucharest, Department of Chemistry, Bd. Republicii, 13, Bucharest R-70346, Romania

3. Università degli Studi, Dipartimento di Chimica, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, Florence I-50121, Italy

Abstract

Complexes containing the anions of 5-benzoylamido-1,3,4-thiadiazole-2-sulfonamide and 5-(3-nitro-benzoylamido)-1,3,4-thiadiazole-2-sulfonamid as ligands, and V(IV); Cr(III); Fe(III); Co(II); Ni(II); Cu(II) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, and EPR spectroscopy; TG, magnetic and conductimetric measurements). The original sulfonamides and their metal complexes are strong inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology

Link

http://downloads.hindawi.com/archive/1997/726234.pdf

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