In VitroSelection of Cancer Cell-Specific Molecular Recognition Elements from Amino Acid Libraries-Reference-Cited by-同舟云学术

In VitroSelection of Cancer Cell-Specific Molecular Recognition Elements from Amino Acid Libraries

Published:2015 Issue: Volume:2015 Page:1-12
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Williams Ryan M.¹²,Sooter Letha J.²

Affiliation:

1. Memorial Sloan Kettering Cancer Center, Molecular Pharmacology & Chemistry, 1275 York Avenue, New York, NY 10065, USA

2. Basic Pharmaceutical Sciences, West Virginia University, 1 Medical Center Drive, P.O. Box 9530, Morgantown, WV 26506, USA

Abstract

Differential cell systematic evolution of ligands by exponential enrichment (SELEX) is anin vitroselection method for obtaining molecular recognition elements (MREs) that specifically bind to individual cell types with high affinity. MREs are selected from initial large libraries of different nucleic or amino acids. This review outlines the construction of peptide and antibody fragment libraries as well as their different host types. Common methods of selection are also reviewed. Additionally, examples of cancer cell MREs are discussed, as well as their potential applications.

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2015/186586.pdf

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