Effects of Cryotherapy on the Maxillary Antrostomy Patency in a Rabbit Model of Chronic Rhinosinusitis

Author:

Gocea Anamaria1,Taulescu Marian2,Trombitas Veronica1,Albu Silviu1ORCID

Affiliation:

1. II-nd Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Street Republicii No. 18, 400015 Cluj-Napoca, Romania

2. Pathology Department, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania

Abstract

It is acknowledged that many causes of failures in endoscopic sinus surgery are related to scarring and narrowing of the maxillary antrostomy. We assessed the effect of low-pressure spray cryotherapy in preventing the maxillary antrostomy stenosis in a chronic rhinosinusitis (CRS) rabbit model. A controlled, randomized, double-blind study was conducted on 22 New Zealand rabbits. After inducing unilateral rhinogenic CRS, a maxillary antrostomy was performed and spray cryotherapy was employed on randomly selected 12 rabbits, while saline solution was applied to the control group (n=10). The antrostomy dimensions and the histological scores were assessed 4 weeks postoperatively. The diameter of cryotreated antrostomy was significantly larger at 4 weeks than that in the control group. At 4 weeks, the maxillary antrostomy area in the study group was significantly larger than the mean area in the control group (103.92 ± 30.39 mm2versus 61.62 ± 28.35 mm2,P=0.002). Submucosal fibrous tissues and leukocytic infiltration in saline-treated ostia were more prominent than those in cryotreated ostia with no significant differences between the two groups regarding the histological scores. Intraoperative low-pressure spray cryotherapy increases the patency of the maxillary antrostomy at 4 weeks postoperatively with no important local side effects.

Funder

Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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