Lung Dendritic Cell Developmental Programming, Environmental Stimuli, and Asthma in Early Periods of Life

Author:

Awasthi Shanjana1,Singh Bhupinder1ORCID,Welliver Robert C.2,Dietert Rodney R.3

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA

2. Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA

3. Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA

Abstract

Dendritic cells (DCs) are important cells of our innate immune system. Their role is critical in inducing adaptive immunity, tolerance, or allergic response in peripheral organs—lung and skin. The lung DCs are not developed prenatally before birth. The DCs develop after birth presumably during the first year of life; exposures to any foreign antigen or infectious organisms during this period can significantly affect DC developmental programming and generation of distinct DC phenotypes and functions. These changes can have both short-term and long-term health effects which may be very relevant in childhood asthma and predisposition for a persistent response in adulthood. An understanding of DC development at molecular and cellular levels can help in protecting neonates and infants against problematic environmental exposures and developmental immunotoxicity. This knowledge can eventually help in designing novel pharmacological modulators to skew the DC characteristics and immune responses to benefit the host across a lifetime.

Publisher

Hindawi Limited

Subject

Immunology and Allergy

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