Pulmonary Phaeohyphomycosis Caused byPhaeoacremoniumin a Kidney Transplant Recipient: Successful Treatment with Posaconazole

Author:

Monaganti Saivaralaxmi1,Santos Carlos A. Q.1,Markwardt Andrea2,Pence Morgan A.3,Brennan Daniel C.1

Affiliation:

1. The Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Renal Division/Campus Box 8126, St. Louis, MO 63110, USA

2. Barnes-Jewish Hospital, Center for Outpatient Health, 4901 Forest Park Avenue, 5th Floor, St. Louis, MO 63108, USA

3. Department of Pathology & Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8118, St. Louis, MO 63110, USA

Abstract

We report a rare case of pulmonary phaeohyphomycosis in a 49-year-old woman 6 years after kidney transplantation. She presented with dyspnea, cough, and fatigue. Her chest CT scan revealed nodular opacities in the right upper lung. A fine needle aspirate biopsy culture yieldedPhaeoacremoniumand surgical pathology of the biopsy showed chronic inflammation. We successfully treated her with posaconazole and managed drug interactions between posaconazole and tacrolimus. This is the second reported case of biopsy-proven pulmonary infection byPhaeoacremoniumin a kidney transplant recipient and successfully treated with posaconazole.

Publisher

Hindawi Limited

Subject

General Medicine

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