Trypanosoma cruziInfection and Host Lipid Metabolism

Abstract

Trypanosoma cruziis the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated inT. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein (LDL), low density lipoprotein receptor (LDLR), and high density lipoprotein (HDL). All of these factors are required to maintain host lipid homeostasis and are intricately connected via several metabolic pathways. We reviewed the interaction ofT. cruziwith each of the relevant host components, in order to further understand the roles of host lipid metabolism inT. cruziinfection. This review sheds light on the potential impact ofT. cruziinfection on the status of host lipid homeostasis.