Affiliation:
1. Istanbul University, Faculty of Engineering Science, Department of Chemistry, Avcılar, Istanbul, Turkey
2. Istanbul University, Faculty of Pharmacy, Department of Microbiology, Beyazid, Istanbul, Turkey
Abstract
The metal complexes of nine 2-substituted-1H-benzimidazoles (I-IX) with Ni(II), Pd(II), Cu(II),
Ag(I), Zn(II) salts were synthesized. The compounds were characterized by melting point, analytical data, IR
spectroscopy and magnetic susceptibility. The antimicrobial activity of the compounds was determined by
the disk diffusion method in Mueller-Hinton Agar on Staphylococcus aureusATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis, Candida albicans ATCC 10231. Cu(II)and Ag(I)complexes of II, III and IV showed considerable activity against S. aureus, S. epidermidis, Ps. aeruginosa, S. typhi, Sh. flexneri and C. albicans microorganisms, the ligands themselves
having no effect.
Subject
Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology
Cited by
15 articles.
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