The Association of Thyroid-Stimulating Hormone (TSH) Levels and Lipid Profile in Euthyroid Patients with Familial Hypercholesterolemia

Abstract

Previous studies reported a relationship between thyroid-stimulating hormone (TSH) and low-density lipoprotein cholesterol (LDL-C) levels. In this study, we aim to evaluate the impact of TSH levels on lipid profile in patients with familial hypercholesterolemia (FH) and euthyroid state. Patients were selected from the Isfahan FH registry. The Dutch Lipid Clinic Network (DLCN) criteria are used to detect FH. Patients were classified into no FH, possible FH, probable FH, and definite FH groups based on the DLCN scores. Patients with any cause of secondary hyperlipidemia, including hypothyroidism, were excluded from this study. The study group consisted of 103 patients with possible FH, 25 patients with definite FH, and 63 individuals with no FH. The mean TSH and LDL-C levels among participants were $2.10\pm 1.22$  mU/l and $142.17\pm 62.56$  mg/dl, respectively. No positive or negative correlation was found between serum TSH and total cholesterol ( $P$ value = 0.438), high-density lipoprotein cholesterol ( $P=0.225$ ), triglycerides ( $P$ value = 0.863), and LDL-C ( $P$ value = 0.203). We found no correlation between serum TSH levels and lipid profiles in euthyroid patients with FH.