Preoperative ICG Test to Predict Posthepatectomy Liver Failure and Postoperative Outcomes in Hilar Cholangiocarcinoma

Author:

Li Min1,Wang Jie1,Song Jieqiong2,Shen Feng3,Song Lujun1,Ni Xiaoling1,Suo Tao1,Liu Han1,Zhong Ming2ORCID,Liu Houbao1ORCID

Affiliation:

1. Department of General Surgery, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Shanghai 200032, China

2. Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Shanghai 200032, China

3. Department of Medical Oncology, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Shanghai 200032, China

Abstract

Preoperative evaluation of hepatic functional reserve in patients with hilar cholangiocarcinoma (hCCA) has vital clinical significance for prevention of posthepatectomy liver failure (PHLF) and mortality. The aim of the present study was to evaluate the clinical significance of the indocyanine green retention rate at 15 minutes (ICG R15) and related factors of postoperative outcomes in patients with hCCA. 147 patients who scheduled for hCCA resection underwent a preoperative ICG test between May 2015 and May 2020 and were prospectively analyzed. Single-factor analysis was used to evaluate the risk factors for PHLF and postoperative outcomes in hCCA. After univariate analysis, significant differences in ICG R15 were found between the PHLF group and the liver function recovered well (LFRW) group ( P 0.05 ). In terms of postoperative complications, ICG R15 was also a risk factor for moderate-to-severe postoperative complications. Preoperative ICG R15 was significantly associated with PHLF and moderate-to-severe postoperative complications. ICG R15 may become an ideal clinical indicator for the evaluation of liver function reserve before hCCA and can better predict the postoperative complications.

Funder

Most Important Clinical Medical Center and Key Discipline Construction of Shanghai

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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