miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1-Reference-Cited by-同舟云学术

miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1

Published:2013 Issue: Volume:2013 Page:1-8
ISSN:2090-2247
Container-title:Biochemistry Research International
language:en
Short-container-title:Biochemistry Research International

Author:

Ke Yang¹,Zhao Weiyong²,Xiong Jie¹,Cao Rubo¹^ORCID

Affiliation:

1. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

2. Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China

Abstract

MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT phenotype of NSCLC cells. miR-149 inhibited EMT in NSCLC cells. Furthermore, we demonstrated that miR-149 directly targeted Forkhead box M1 (FOXM1), and FOXM1 was involved in the EMT induced by TGF-β1 in A549 cells. Overexpression of FOXM1 restored EMT process inhibited by miR-149. Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells.

Publisher

Hindawi Limited

Subject

Biochemistry

Link

http://downloads.hindawi.com/journals/bri/2013/506731.pdf

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