Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise-Reference-Cited by-同舟云学术

Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise

Published:2017 Issue: Volume:2017 Page:1-6
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Chung Jin-Young¹^ORCID,Kim Min-Wook²³,Im Wooseok⁴,Hwang In Koo⁵^ORCID,Bang Moon-Suk⁶,Kim Manho⁴⁷^ORCID

Affiliation:

1. Department of Veterinary Internal Medicine and Geriatrics, College of Veterinary Medicine, Kangwon National University, Gangwon-do 200-701, Republic of Korea

2. Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seoul 150-713, Republic of Korea

3. Institute of Catholic Integrative Medicine (ICIM), Incheon St. Mary’s Hospital, Incheon 403-720, Republic of Korea

4. Department of Neurology, Seoul National University Hospital, 101 Daehakro, Chongno-ku, Seoul 03080, Republic of Korea

5. Departments of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea

6. Department of Rehabilitation Medicine, Seoul National University Hospital, 101 Daehakro, Chongno-ku, Seoul 03080, Republic of Korea

7. Neuroscience and Protein Metabolism Medical Research Center, Seoul National University, College of Medicine, 101 Daehakro, Chongno-ku, Seoul 03080, Republic of Korea

Abstract

Neurotrophin-3 (NT-3) is a neurotrophic factor that mainly binds to the tyrosine kinase C (trkC) receptor. NT-3 has been shown to have neuroprotective effects in focal cerebral ischemia. Exercise also has ability to induce functional recovery in focal cerebral ischemia. However, the relationship between NT-3, its receptor trkC, and exercise has not been revealed. In this study, we assessed the expressions of NT-3 and trkC in focal cerebral ischemia. We also assessed the expression of NT-3 and trkC with treadmill exercise in focal cerebral ischemia. The results showed that, in a permanent middle cerebral artery occlusion rat model, exercise increased NT-3 and trkC expression. However, the patterns of expression of NT-3 and trkC at different time points varied. These results suggest that exercise-induced functional recovery in focal cerebral ischemia was related to NT-3 and trkC, but the role on times of NT-3 and trkC differed, although trkC is the receptor kinase for NT-3.

Funder

Ministry of Science, ICT and Future Planning

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2017/9248542.pdf

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