Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity-Reference-Cited by-同舟云学术

Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity

Published:2019-04-17 Issue: Volume:2019 Page:1-10
ISSN:1687-6334
Container-title:Advances in Pharmacological Sciences
language:en
Short-container-title:Advances in Pharmacological Sciences

Author:

Elsharif Asma M.¹^ORCID,Youssef Tamer E.¹²^ORCID,Al-Jameel Suhailah S.¹,Mohamed Hanan H.¹²,Ansari Mohammad Azam³^ORCID,Rehman Suriya³,Akhtar Sultan⁴

Affiliation:

1. Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia

2. Basic and Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia

3. Department of Epidemic Disease Research, Institute of Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

4. Department of Physics Research, Institute of Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

Abstract

The aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)4NiPcs 4a–d. The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activity of the newly synthesized (qz)4NiPcs 4a–d against Escherichia coli. The minimum MICs and MBCs value were recorded for compounds 4a, 4b, 4c, and 4d, respectively. The results indicated that the studied (qz)4NiPcs 4a–d units possessed a broad spectrum of activity against Escherichia coli. Their antibacterial activities were found in the order of 4d > 4c > 4b > 4a against Escherichia coli, and the strongest antibacterial activity was achieved with compound 4d.

Funder

National Research Centre

Publisher

Hindawi Limited

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine

Link

http://downloads.hindawi.com/journals/aps/2019/5964687.pdf

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