Acute Hepatitis Induced by Intravesical BCG Therapy: A Rare but Serious Complication

Author:

Abid Hakima12ORCID,Figuigui Mouna12ORCID,Adil Ibrahimi Sidi12ORCID,El Abkari Mohamed12,Mzyiene Mohamed23ORCID,Ennaciri Soufiane23ORCID,Justin Ziba Ouima23ORCID,Fassi Mohamed Jamal El23ORCID,Tahiri Elousrouti Layla24ORCID,Chbani Laila24

Affiliation:

1. Department of Hepato-Gastroenterology, University Hospital Hassan II-Fez, Laboratory of Human Pathology, Biomedicine and Environment, Fes, Morocco

2. Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University Fez-Morocco, Fes, Morocco

3. Urology Department-University Hospital Hassan II-Fez, Fes, Morocco

4. Pathological Anatomy Department, University Hospital Hassan II of Fez, Fes, Morocco

Abstract

Bacillus Calmette and Guérin (BCG), widely used as a vaccination to prevent tuberculosis, is also used as immunotherapy, by intrabladder instillation, to treat superficial bladder cancers and prevent recurrence. Complications following instillation of BCG are most often localized reactions, such as cystitis or hematuria. They can more rarely be generalized and potentially severe such as hepatitis, pneumopathies, aortitis, and localization to hematopoietic tissue. We have reported the observation of a 47-year-old patient followed up for a bladder tumor operated for transurethral resection of the bladder, then having benefited from an instillation of BCG therapy complicated by occurrence a week later of an acute hepatitis. The diagnostic time was 2 days, and the outcome was favorable with corticosteroid therapy.

Publisher

Hindawi Limited

Subject

General Medicine

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