Affiliation:
1. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan City, China
2. Department of Pathology and Pathophysiology, Shandong Medical College, Jinan City, China
Abstract
The influence of diabetes and associated sex differences on cerebral white matter lesions (WML) is unclear. We used data from a cross-sectional study uploaded to the DATADRYAD website by Shinkawa et al. to investigate differences in the association between hemoglobin A1c (HbA1c) levels and cerebral WML between men and women. The average age of all participants was
years old, and approximately 51.89% of them were men. A linear relationship between HbA1c and cerebral WML was detected in men. Fully adjusted binary logistic regression showed no association of HbA1c with cerebral WML in men. A nonlinear relationship between HbA1c and cerebral WML was detected in women, whose cutoff point was 5.6%. The effect sizes and confidence intervals of the left and right sides of the inflection point were
(95% CI 0.06, 0.69,
) and
(95% CI 1.50, 8.15,
), respectively. In the higher HbA1c group, further subgroup analysis showed a stronger association between HbA1c and cerebral WML in women (
, 95% CI 1.68, 8.72
) than in men (
, 95% CI 0.76, 1.36
) (
for interaction with sex was 0.0004). A stronger effect of HbA1c on the risk of cerebral WML in women than in men was found in the higher HbA1c group.
Subject
Neurology (clinical),Neurology,General Medicine