Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey

Author:

Aslan Ibrahim1,Canatan Duran2,Balta Nihal3,Kacar Gulizar4,Dorak Cengaver3,Ozsancak Ahmet3,Oguz Nurgul3,Cosan Ruya3

Affiliation:

1. Department of Endocrinology and Metabolism, Antalya Education and Research Hospital, 07100 Antalya, Turkey

2. Hemoglobinopathy Diagnosis Center, Mediterranean Blood Diseases Foundation and Thalassemia Federation of Turkey, Antalya, Turkey

3. Antalya State Hospital, 07100 Antalya, Turkey

4. Department of Nuclear Medicine, Antalya Education and Research Hospital, 07100 Antalya, Turkey

Abstract

Aim. We assessed the bone mineral density and related parameters in nine adults, thirty-eight pubertal, prepubertal totally forty-seven patients with thalassemia major living in Antalya, Turkey.Materials and Methods. We measured height and pubertal staging in last five years by six-month intervals. Average ferritin and hemoglobin concentrations were calculated for last three years. The levels of hydroxyproline, calcium, phosphorus, and creatinine were measured in 24 h urine, and those of parathormone, IGF 1, osteocalcine, alkaline phosphatase, calcium, ionized calcium, magnesium, phosphorus, creatine, blood glucose, thyroid stimulating hormone, alanine transaminase, and aspartate transaminase were determined in serum, and also the bone mineral density was measured.Results. The average L1–L4 bone mass density was27.1±10.1 g cm−2; the average bone mineral content was0.65±0.11 g. of the patients with a Z-score under 2.5. A moderate relationship was found between the bone mass density age and height. Subjects in low pubertal staging and short stature (<3% percentile) have significantly lower bone mass densitiesP<0.001.Conclusion. he prevalence of osteoporosis is high in patients with thalassemia major, possibly related to delayed puberty.

Publisher

Hindawi Limited

Subject

Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

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