Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand-Reference-Cited by-同舟云学术

Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

Published:2011-06-30 Issue: Volume:2011 Page:1-9
ISSN:2090-1364
Container-title:Hepatitis Research and Treatment
language:en
Short-container-title:Hepatitis Research and Treatment

Author:

Galy Olivier¹,Chemin Isabelle¹,Le Roux Emilie²,Villar Stéphanie²,Le Calvez-Kelm Florence²,Lereau Myriam¹,Gouas Doriane²,Vieco Beatriz³,Suarez Iris⁴,Navas Maria-Cristina⁴,Chevallier Michèle⁵,Norder Helene⁶,Srivatanakul Petcharin⁷,Karalak Anant⁷,Sangrajrang Suleeporn⁸,Trépo Christian¹,Hainaut Pierre²

Affiliation:

1. INSERM U1052, 151 Cours Albert Thomas, 69003 Lyon, France

2. International Agency for Research on Cancer, 150 Cours Albert Thomas, Cedex 08, 69372 Lyon, France

3. Departamento de Patología, Universidad de Antioquia, SIU, Carrera 51 no. 61-30, Medellín, Colombia

4. Grupo de Gastrohepatología, Universidad de Antioquia, SIU, Carrera 51 no. 61-30, Medellín, Colombia

5. Biomnis, Anatomie et Cytologie Pathologiques, 17/19 Avenue Tony Garnier, 69007 Lyon, France

6. Department of Virology, Swedish Institute for Infectious Disease Control (Smittskyddsinstitutet, SMI), Solna, Sweden

7. Cancer Control Unit, National Cancer Institute, 268/1 Rama VI Road, Bangkok 10400, Thailand

8. Research Division, National Cancer Institute, Rama VI Road, Bangkok 10400, Thailand

Abstract

Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.

Funder

ECOS-Nord

Publisher

Hindawi Limited

Subject

Hepatology

Link

http://downloads.hindawi.com/archive/2011/697162.pdf

Reference42 articles.

1. Epidemiology of hepatocellular carcinoma

2. Development of Hepatocellular Carcinoma Among Patients with Chronic Liver Disease due to Hepatitis C Viral Infection

3. p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from thailand