NOCTURNIN Gene Diurnal Variation in Healthy Volunteers and Expression Levels in Shift Workers

Author:

Bracci Massimo1ORCID,Copertaro Alfredo2,Ciarapica Veronica1,Barbaresi Mariella2ORCID,Esposito Stefano2,Albanesi Antonella3,Valentino Matteo1,Ledda Caterina4ORCID,Rapisarda Venerando4,Santarelli Lory1ORCID

Affiliation:

1. Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy

2. Healthcare Workers Service, ASUR Area 2, Loreto Hospital, Loreto, Italy

3. Nutrition Service, ASUR Area 2, Loreto Hospital, Loreto, Italy

4. Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

Abstract

Objective. The NOCTURNIN gene links nutrient absorption and metabolism to the circadian clock. Shift workers are at a heightened risk of overweight and of developing obesity and metabolic syndrome. This study investigates the diurnal variation of NOCTURNIN in healthy volunteers and its expression levels in rotational shift and daytime workers. Methods. NOCTURNIN expression levels were evaluated in peripheral blood lymphocytes from 15 healthy volunteers at 4-hour intervals for 24 h. Metabolic parameters and NOCTURNIN expression were measured in workers engaged in shift and daytime work. Results. In the group of volunteers NOCTURNIN expression showed diurnal variation, with a peak at 8:00 AM. NOCTURNIN expression was higher in shift workers than in daytime workers. Multivariate analysis confirmed the role of shift work as an independent factor affecting NOCTURNIN expression. Notably, its level correlated directly with body mass index and inversely with total energy expenditure. Conclusions. Measuring NOCTURNIN expression levels in human peripheral blood lymphocytes can improve investigations on the relationship between changes in circadian rhythm and metabolic disorders. Shift workers show higher NOCTURNIN levels than daytime workers.

Funder

Polytechnic University of Marche

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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