Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia

Author:

Roman-Gonzalez Alejandro1ORCID,Naranjo Carlos Andrés2ORCID,Cardona-Maya Walter D.13ORCID,Vallejo Dionis4,Garcia Francisco45,Franco Cesar6,Alvarez Leonor1,Tobón Luis Ignacio1,López Marta Ibeth1,Rua Carolina1,Bedoya Gabriel2ORCID,Cadavid Ángela13ORCID,Torres José Domingo1ORCID

Affiliation:

1. Grupo de Investigación en Trombosis, Universidad de Antioquia-UdeA, Colombia

2. Grupo GENMOL, Universidad de Antioquia-UdeA, Colombia

3. Grupo Reproducción, Universidad de Antioquia-UdeA, Colombia

4. Departamento de Neurología, Universidad de Antioquia-UdeA, Colombia

5. Departamento de Neurología, Hospital Universitario San Vicente Fundación, Colombia

6. Instituto Neurológico de Antioquia, Colombia

Abstract

Objective. To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention. Materials and Methods. Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test. Results. Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis ( p = 0.004 ). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia. Conclusion. Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.

Funder

Colciencias and Universidad de Antioquia

Publisher

Hindawi Limited

Subject

Clinical Neurology

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