Affiliation:
1. Institute of Pediatrics, Department of Neonatology, Developmental and Behavioral Pediatric Department & Child Health Care Department, Children’s Hospital of Fudan University, Fudan University, Shanghai, China
2. Center for Clinical Research and Translational Medicine, Department of Neurology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China
3. Tenth People’s Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China
Abstract
Parkinson’s disease (PD) is a complex neurodegenerative disease, manifested by the progressive functional impairment of the midbrain nigral dopaminergic neurons. Due to the unclear underlying pathogenesis, disease-modifying drugs for PD remain elusive. In Asia, such as in China and India, herbal medicines have been used in the treatment of neurodegenerative disease for thousands of years, which recently attracted considerable attention because of the development of curative drugs for PD. In this review, we first summarized the pathogenic factors of PD including protein aggregation, mitochondrial dysfunction, ion accumulation, neuroinflammation, and oxidative stress, and the related recent advances. Secondly, we summarized 32 Chinese herbal medicines (belonging to 24 genera, such as Acanthopanax, Alpinia, and Astragalus), 22 Chinese traditional herbal formulations, and 3 Indian herbal medicines, of which the ethanol/water extraction or main bioactive compounds have been extensively investigated on PD models both in vitro and in vivo. We elaborately provided pictures of the representative herbs and the structural formula of the bioactive components (such as leutheroside B and astragaloside IV) of the herbal medicines. Also, we specified the potential targets of the bioactive compounds or extractions of herbs in view of the signaling pathways such as PI3K, NF-κB, and AMPK which are implicated in oxidative and inflammatory stress in neurons. We consider that this knowledge of herbal medicines or their bioactive components can be favorable for the development of disease-modifying drugs for PD.
Funder
National Natural Science Foundation of China
Subject
Cell Biology,Ageing,General Medicine,Biochemistry
Cited by
30 articles.
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