Affiliation:
1. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
2. Fangshan Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
3. Beijing University of Chinese Medicine, Beijing, China
Abstract
Doxorubicin (DOX) is a class of effective chemotherapeutic agents widely used in clinical practice. However, its use has been limited by cardiotoxicity. The mechanism of DOX-induced cardiotoxicity (DIC) is complex, involving oxidative stress, Ca2+ overload, inflammation, pyroptosis, ferroptosis, apoptosis, senescence, etc. Exosomes (EXOs), as extracellular vesicles (EVs), play an important role in the material exchange and signal transmission between cells by carrying components such as proteins and RNAs. More recently, there has been a growing number of publications focusing on the protective effect of EXOs on DIC. Here, this review summarized the main mechanisms of DIC, discussed the mechanism of EXOs in the treatment of DIC, and further explored the value of EXOs as diagnostic biomarkers and therapeutic strategies for DIC.
Funder
National Key R&D Program of China
Subject
Cell Biology,Aging,General Medicine,Biochemistry
Cited by
3 articles.
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