Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model-Reference-Cited by-同舟云学术

Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model

Published:2011-04-28 Issue: Volume:2011 Page:1-7
ISSN:2090-1712
Container-title:International Journal of Molecular Imaging
language:en
Short-container-title:International Journal of Molecular Imaging

Author:

Chakera A. H.¹,Nielsen B. S.²³,Madsen J.⁴,Romer J.²⁵,Kristjansen P. E. G.⁵⁶,Buch I.⁷,Binderup T.⁸,Ingvar C.⁹,Nalla A.¹⁰,Kjaer A.⁴⁸,Hesse B.⁴

Affiliation:

1. Clinic of Plastic Surgery, Breast Surgery and Burns Unit, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

2. The Finsen Laboratory, Rigshospitalet, 2100 Copenhagen, Denmark

3. Diagnostic Product Development Division, Exiqon A/S, 2950 Vedbaek, Denmark

4. Clinic of Clinical Physiology, Nuclear Medicine, and PET, Rigshospitalet, 2950 Copenhagen, Denmark

5. Novo Nordisk A/S, 2880 Bagsvaerd, Denmark

6. Institute of Molecular Pathology, University of Copenhagen, 1165 Copenhagen, Denmark

7. Faculty of Medical Laboratory Science, Metropolitan University College, 1150 Copenhagen, Denmark

8. Cluster for Molecular Imaging, Faculty of Health Sciences, University of Copenhagen, 1165 Copenhagen, Denmark

9. Department of Surgery, Lunds University Hospital, 221 85 Lund, Sweden

10. Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 1165 Copenhagen, Denmark

Abstract

Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

Funder

Vibe A. Linholter Estate

Publisher

Hindawi Limited

Subject

Radiology Nuclear Medicine and imaging

Link

http://downloads.hindawi.com/archive/2011/828151.pdf

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