An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines-Reference-Cited by-同舟云学术

An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines

Published:2014 Issue: Volume:2014 Page:1-10
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Dong Bo¹,Zarlenga Dante S.²,Ren Xiaofeng¹

Affiliation:

1. Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin 150030, China

2. Animal Parasitic Diseases Laboratory, Agricultural Research Service, Beltsville, MD 20705, USA

Abstract

Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals.

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2014/824630.pdf

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4. Simultaneous Deletion of Pseudorabies Virus Tegument Protein UL11 and Glycoprotein M Severely Impairs Secondary Envelopment

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