Assessment on the Toxic Effects of Chemically Synthesized SPIONs against Model Organisms

Author:

Justin Chellapan1,Samrot Antony V.2ORCID,Shobana Nagarajan1ORCID,Sathiyasree Mahendran1,Saigeetha Subramanian3,Remya Rajan Renuka4ORCID,Rajalakshmi Deenadhayalan1,Prasath S.5ORCID

Affiliation:

1. Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai 600119, Tamil Nadu, India

2. School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP2, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia

3. Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India

4. Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai 600073, Tamil Nadu, India

5. Department of Mechanical Engineering, College of Engineering and Technology, Mizan Tepi University, Mizan Teferi, Ethiopia

Abstract

The remarkable physicochemical properties of nanomaterials have attracted researchers due to the numerous applications in the field of chemistry, biology, and physics. Despite the various applications, superparamagnetic iron oxide nanoparticles (SPIONs) are harmful to living organisms and to the environment as they are released without any safety testing. In this study, SPIONs were synthesized and further characterized. The aim of the study was to examine the toxicity of synthesized SPIONs against animal models: Zebrafish—Danio rerio, Earthworm—Eudrilus eugeniae, and Drosophila—Drosophila melanogaster through histology using Hematoxylin–Eosin and Prussian Blue staining. The accumulation of SPIONs was further quantified by using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Through histology images, it was observed that the SPIONs had caused damages and a lower concentration of 0.001–0.002 μg/ml of metal accumulation was detected in the ICP-MS analysis.

Publisher

Hindawi Limited

Subject

General Materials Science

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