Preoperative Cryopreservation Promotes Digital Survival after Digit Replantation

Abstract

Cryopreservation has been applied in the replantation of limbs with a minimal amount of muscle tissue replanted. And small composite tissues have also been reported to be successfully replanted by preoperative cryopreservation. In this study, we aimed to study the effect of preoperative cryopreservation on digital survival after digit replantation. Accordingly, we collected and compared the demographic and clinicopathological characteristics of patients with digit injury of patients, and we observed no significant difference between the NT and CP patients of digital injury. We also investigated the records of successful digit replantation and other parameters which influenced the odds of digital survival of all recruited patients. Accordingly, we found that the number of survived digits was remarkably increased in patients in the CP group compared with that in patients in the NT group. And the number of patients requiring blood transfusion and the mean length of hospital stay were notably decreased in the CP group. And compared with other patient characteristics, the mechanism of injury (blade, crush, or avulsion) showed a remarkable difference between the two groups of digital failure. Moreover, we analyzed the correlations between patient characteristics and the odds of digit survival and found that compared with other basic characteristics of patients and their injury, the preservation temperature, especially cryopreservation, could significantly promote digital survival after replantation.