Affiliation:
1. Department of Chemistry, Faculty of Science and Agriculture, University of Limpopo, Private Bag X1106, Sovenga 0727, Polokwane, South Africa
Abstract
This study focussed on the synthesis of sulfamethoxazole derivatives and their biological evaluation. The sulfamethoxazole derivatives were successfully biologically evaluated against Mycobacterium tuberculosis, Staphylococcus aureus, and Chinese Hamster Ovarian (CHO) cells. The biological evaluation revealed compounds with improved antitubercular activity and antibacterial activity against S. aureus as well as safety profile when compared to the starting material, sulfamethoxazole. The most active compounds against Mycobacterium tuberculosis were3q with 92% inhibition followed by 3s (90%), 3k (88%), 3t (85%), and 3o (84%).
Reference30 articles.
1. Study of a series of cobalt(II) sulfonamide complexes: Synthesis, spectroscopic characterization, and microbiological evaluation against M. tuberculosis. Crystal structure of [Co(sulfamethoxazole)2(H2O)2]·H2O
2. Impact of the covid-19 pandemic on TB detection and mortality in 2020;Who;Journal of Chemical Information and Modeling,2021
3. Tuberculosis
4. South african national essential medicine list adult hospital level medication review process component: gynaecology;E. Bera;Expert review of anti-infective therapy,2017
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