The Impact of Curcumin on the Inflammatory Profile of SW982 Cells in a Rheumatoid Arthritis Model

Author:

Więcek Kamil1ORCID,Kupczyk Piotr1ORCID,Chodaczek Grzegorz2ORCID,Woźniak Marta1ORCID

Affiliation:

1. Department of Clinical and Experimental Pathology, Wroclaw Medical University, Marcinkowskiego 1, 50-368 Wroclaw, Poland

2. Bioimaging Laboratory, Łukasiewicz Research Network-PORT Polish Center for Technology Development, Stablowicka 147, 54-066 Wroclaw, Poland

Abstract

Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases, affecting approximately 1% of the total global population. Curcumin, a natural polyphenol is a substance that could potentially mitigate the course of this disease. To evaluate curcumin’s anti-inflammatory impact on synoviocytes in the RA model, a set of experiments was conducted on SW982 cells, stimulated by IL-1β, IL-6, or TNF-α to emulate inflammation. During the research, the curcumin effect was evaluated by measuring cell survivability, expression of MMP1 gene, subcellular localization of P70S6K1 protein, and its phosphorylated form and amount of produced IL-6 and TNF-α. Results of conducted experiments presented a positive impact of curcumin on synoviocytes in the RA model, by reducing SW982 cells’ survivability, decreasing levels of MMP1 gene expression and TNF-α protein production, which altogether confirm beneficial effects of the curcumin therapy in a RA in vitro model.

Funder

Wroclaw Medical University

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

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