Pinin Induces Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma by Regulating m6A Modification-Reference-Cited by-同舟云学术

Pinin Induces Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma by Regulating m6A Modification

Published:2021-12-07 Issue: Volume:2021 Page:1-11
ISSN:1687-8469
Container-title:Journal of Oncology
language:en
Short-container-title:Journal of Oncology

Author:

Qiao Kailiang¹,Chen Caihong¹,Liu Haoyang¹,Qin Yuan²^ORCID,Liu Huijuan¹^ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China

2. College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China

Abstract

Pinin is a moonlighting protein localized in desmosomes and nucleus. It could promote the growth of hepatocellular carcinoma. Whether this protein can induce epithelial-to-mesenchymal transition (EMT) and malignant progression in HCC is unknown. This work found that Pinin prompts EMT in vitro and in vivo. Further mechanism study found that Pinin increases the level of N6-methyladenosine (m6A) modification of RNA by interacting with METTL3, which in turn induces snail1 expression. These findings suggest that Pinin induces EMT by regulating m6A modification and, thus, could be a potential anticancer target for HCC therapy.

Funder

National Science and Technology Major Project

Publisher

Hindawi Limited

Subject

Oncology

Link

http://downloads.hindawi.com/journals/jo/2021/7529164.pdf

Reference34 articles.

1. Antibodies Differentiate Desmosome-Form and Nucleus-Form Pinin: Evidence That Pinin Is a Moonlighting Protein with Dual Location at the Desmosome and within the Nucleus

2. Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex.

3. Dissection of Protein Linkage between Keratins and Pinin, a Protein with Dual Location at Desmosome-Intermediate Filament Complex and in the Nucleus