Affiliation:
1. Sensor Lab Research Group, Department of Chemical Technology, Midlands State University, Private Bag 9055, Senga, Gweru, Zimbabwe
Abstract
In the present study, simultaneous electrochemical behavior of tenofovir disoproxil fumarate (TDF) and lamivudine (LAM) on a glassy carbon electrode (GCE) modified with a novel nanocomposite, nickel-cobalt sulfide-decorated graphene quantum dots (Ni-CoS/GQDs) was investigated. Characterization of different components used for modifications was achieved using UV-Vis and transmission electron microscopy (TEM). The electrochemistry of TDF and LAM at the modified electrode was examined using cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry, differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). A substantial (+39 mV TDF; +20 mV LAM) decrease in potential on oxidation reaction in 0.1 M PBS (pH 8.0) was achieved due to synergy between Ni-CoS and GQDs. Using optimized voltammetric parameters and pH, DPV gave a linear calibration over the range 5-18 μM for TDF and LAM. The detection limits were calculated as 2.42×10−8 mM (LAM) and 1.21×10−8 mM (TDF). The estimated values for Gibbs free energy revealed adsorption of TDF and LAM on Ni-CoS/GQDs/GCE as a spontaneous and favorable process. The voltammetric method was applied for determination of LAM and TDF in a pharmaceutical formulation giving average recovery of 99.65%.
Funder
Midlands State Research Board
Subject
Electrical and Electronic Engineering,Instrumentation,Control and Systems Engineering
Cited by
12 articles.
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