The Effects of L-Arginine on Liver Damage in Experimental Acute Cholestasis an Immunohistochemical Study

Author:

Ozsoy Yucel1,Ozsoy Mustafa1,Coskun Teoman2,Namlı Kemal3,Var Ahmet4,Özyurt Beyhan5

Affiliation:

1. Department of General Surgery, Manisa State Hospital, Manisa, 35630 İzmir, Turkey

2. Department of General Surgery, School of Medicine, Celal Bayar University, 45000 Manisa, Turkey

3. Department of Immunopathology, School of Medicine, Celal Bayar University, 45000 Manisa, Turkey

4. Department of Biochemistry, School of Medicine, Celal Bayar University, 45000 Manisa, Turkey

5. Department of Public Health and Biostatistics, School of Medicine, Celal Bayar University, 45000 Manisa, Turkey

Abstract

Obstructive jaundice damages critical functions in the liver. Nitric oxide modulation would influence liver damage induced by biliary obstruction, and little is known about it Acute cholestasis was induced by bile duct ligation (BDL) in two groups of male Sprague-Dawley rats. L-Arginine or serum physiologic was administered to treatment and control group. Histopathological and immunohistochemical iNOS expression was investigated in hepatic tissue. Plasma enzyme activities were increased in acute cholestasis, and that L-arginine treatment partially but significantly prevented the elevation of these markers of liver damage (P< .05). Also histopathology scoring showed that the liver injury was prevented and immunohistochemical iNOS activity was increased significantly in L-arginine group (P< .05). This study shows that, after 7 days of biliary obstruction, liver damage is well established and exogenous L-arginine treatment partially but significantly prevented the liver injury in acute cholestasis.

Publisher

Hindawi Limited

Subject

Hepatology,Surgery

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