Association of Low Molecular Weight Plasma Aminothiols with the Severity of Coronavirus Disease 2019

Author:

Kryukov Evgeny Vladimirovich1ORCID,Ivanov Alexander Vladimirovich2ORCID,Karpov Vladimir Olegovich1,Vasil’evich Alexandrin Valery2,Dygai Alexander Mikhaylovich2ORCID,Kruglova Maria Petrovna3ORCID,Kostiuchenko Gennady Ivanovich4,Kazakov Sergei Petrovich1,Kubatiev Aslan Amirkhanovich2ORCID

Affiliation:

1. Burdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, 105229 Moscow, Russia

2. Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia

3. Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Trubetskaya St., 8-2, 119991 Moscow, Russia

4. Regional Clinical Hospital, Lyapidevsky St., 1, 656024 Barnaul, Russia

Abstract

Objective. Aminothiols (glutathione (GSH), cysteinylglycine (CG)) may play an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), but the possible association of these indicators with the severity of COVID-19 has not yet been investigated. Methods. The total content ( t ) and reduced forms ( r ) of aminothiols were determined in patients with COVID-19 ( n = 59 ) on admission. Lung injury was characterized by computed tomography (CT) findings in accordance with the CT0-4 classification. Results. Low tGSH level was associated with the risk of severe COVID-19 ( tGSH 1.5 μ M , mild vs. moderate/severe: risk ratio RR = 3.09 , p = 0.007 ) and degree of lung damage ( tGSH 1.8 μ M , CT < 2 vs. CT 2 : RR = 2.14 , p = 0.0094 ). The rGSH level showed a negative association with D-dimer levels ( ρ = 0.599 , p = 0.014 ). Low rCG level was also associated with the risk of lung damage ( rCG 1.3 μ M , CT < 2 vs. CT 2 : RR = 2.28 , p = 0.001 ). Levels of rCG ( ρ = 0.339 , p = 0.012 ) and especially tCG ( ρ = 0.551 , p = 0.004 ) were negatively associated with platelet count. In addition, a significant relationship was found between the advanced oxidation protein product level and tGSH in patients with moderate or severe but not in patients with mild COVID-19. Conclusion. Thus, tGSH and rCG can be seen as potential markers for the risk of severe COVID-19. GSH appears to be an important factor to oxidative damage prevention as infection progresses. This suggests the potential clinical efficacy of correcting glutathione metabolism as an adjunct therapy for COVID-19.

Funder

Russian Foundation for Basic Research

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3