Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix-Reference-Cited by-同舟云学术

Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix

Published:2015 Issue: Volume:2015 Page:1-6
ISSN:2090-6706
Container-title:Case Reports in Oncological Medicine
language:en
Short-container-title:Case Reports in Oncological Medicine

Author:

Ong Shawn Y.¹,Taverna Josephine²,Jokerst Clint³^ORCID,Enzler Thomas⁴,Hammode Emad⁴,Rogowitz Elisa⁵,Green Myke R.⁶,Babiker Hani M.²⁷

Affiliation:

1. University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA

2. University of Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USA

3. Department of Radiology, University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA

4. Department of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Avenue, RM 6336, Tucson, AZ 85724, USA

5. Scripps Health, Department of Medicine, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA

6. Department of Pharmacy Services, University of Arizona Medical Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USA

7. Virginia G. Piper Cancer Center Clinical Trials at HonorHealth Research Institute, 10510 N 92nd Street, Suite 200, Scottsdale, AZ 85258, USA

Abstract

Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient’s coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option.

Publisher

Hindawi Limited

Subject

Oncology

Link

http://downloads.hindawi.com/journals/crionm/2015/212543.pdf

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4. Disseminated Intravascular Coagulation with Excessive Fibrinolysis in Prostate Cancer: A Case Series and Review of the Literature

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