Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata-Reference-Cited by-同舟云学术

Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata

Published:2021-01-04 Issue: Volume:2021 Page:1-8
ISSN:1741-4288
Container-title:Evidence-Based Complementary and Alternative Medicine
language:en
Short-container-title:Evidence-Based Complementary and Alternative Medicine

Author:

Dang Phu H.¹²^ORCID,Le Tho H.¹²^ORCID,Do Truong N. V.¹²^ORCID,Nguyen Hai X.¹²^ORCID,Nguyen Mai T. T.¹²³^ORCID,Nguyen Nhan T.¹²³^ORCID

Affiliation:

1. Faculty of Chemistry, University of Science, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, Vietnam

2. Vietnam National University, Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam

3. Cancer Research Laboratory, University of Science, 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam

Abstract

From a CHCl3-soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1) and semetrienone (2), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC50 values of 0.033 and 0.11 μM, respectively. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interactions. Accordingly, semedienone (1) showed good interactions with the peroxide group and amino acid residues. The biosynthesis of the isolated diarylalkanoids was proposed.

Funder

Viet Nam National University Ho Chi Minh City

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

Link

http://downloads.hindawi.com/journals/ecam/2021/8872920.pdf

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