Interleukin-8 Producing Hepatocellular Carcinoma with Pyrexia

Author:

Harimoto Norifumi1,Shirabe Ken2,Abe Tomoyuki1,Kajiyama Kiyoshi1,Nagaie Takashi1,Gion Tomonobu1,Kuroda Yousuke3,Maehara Yoshihiko3

Affiliation:

1. Department of Surgery, Iizuka Hospital, Fukuoka 820-8505, Japan

2. Department of Gastroenterological Surgery, Iizuka Hospital, Fukuoka 820-8505, Japan

3. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Abstract

We discuss a patient who had poorly differentiated HCC with pyrexia and high CRP in laboratory data, which are not commonly observed in the usual HCC. A 50-year-old man with a history of liver dysfunction was admitted with a chief complaint of a prolonged fever and general fatigue. Preoperative diagnosis was HCC with portal vein tumor thrombus. Posterior segmentectomy of the liver and thrombectomy was performed. Rapid tumor recurrence occurred after surgery, and he died 79 days after the operation. Immunohistochemical stain of HCC in this patient revealed the production of proinflammatory cytokine, interleukin-8 (IL-8). IL-8 production may have contributed to the high fever, high inflammatory reaction, and poor prognosis in this case.

Publisher

Hindawi Limited

Subject

Hepatology,Surgery

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