Abstract
This paper reviews the current state of microbial fuel cell (MFC) technology for energy generation. It begins by exploring clean energy alternatives, focusing on waste‐to‐energy solutions, and introduces the concept, applications, and advantages of MFCs. The biochemical processes within MFCs are explained, highlighting how microorganisms metabolize substrates through glycolysis, the Krebs cycle, and the electron transport chain to generate electrons. These electrons flow through an external circuit and combine with protons and oxygen at the cathode to produce water or reduced forms of nitrogen and sulfur. This paper also analyzes 10 key parameters affecting MFC performance: coulombic efficiency, pH, temperature, substrates, organic loading rate, electrode potential, open circuit voltage, treatment efficiency, organic removal rate, and hydraulic retention time. Recent advancements in MFC technology are also discussed, including innovations in reactor configuration and scaling, the development of new membrane materials like earthen and ceramic, and improvements in wastewater treatment methods. The advancements also extend to genetic engineering techniques to enhance microbial efficiency and component modifications, such as the use of carbon‐based nanomaterials and metal catalysts for improved performance, innovations in proton transfer membranes, and mediator‐less MFCs utilizing metal‐reducing bacteria. Challenges facing MFC technology, such as cost, scalability, and environmental sensitivity, are mentioned. The paper concludes with future directions, including the use of advanced materials, integration with wastewater treatment infrastructure, and the potential for nutrient recovery and chemical synthesis. This comprehensive review aims to provide knowledge into optimizing MFCs for sustainable energy generation and environmental benefits.