The Clinical Significance of FilmArray Respiratory Panel in Diagnosing Community-Acquired Pneumonia

Author:

Chen Huanzhu1,Weng Huilan2,Lin Meirui2,He Ping1,Li Yazhen1,Xie Qingdong1,Ke Changwen1ORCID,Jiao Xiaoyang1ORCID

Affiliation:

1. Cell Biology and Genetics Department, Shantou University Medical College, Shantou 515041, China

2. First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

Abstract

Aim. FilmArray Respiratory Panel (FilmArray RP) test is an emerging diagnostic method in fast detecting multiple respiratory pathogens; the methodology and clinical significance of FilmArray RP in community-acquired pneumonia (CAP) diagnosis were evaluated in this study. Methods. Specimens from 74 patients with CAP were analyzed and compared using FilmArray RP, traditional multiple PCR assay, bacterial (or fungal) culture, and serological detection. Results. FilmArray RP and multiplex PCR showed 100% coincidence rate in detecting coronaviruses 229E, OC43, HKU1, and NL63, human metapneumovirus, influenza A and B, and parainfluenza viruses (PIV1, PIV2, and PIV4). There were 15 viral specimens tested as disagreement positive results. FilmArray RP had higher detection rate in detecting dual viral and Mycoplasma pneumoniae infection. The positive bacteria (or fungi) were found in 25 specimens. Conclusions. This study demonstrated the capability of FilmArray RP for simultaneous detection of broad-spectrum respiratory pathogens and potential use in facilitating better patient care.

Funder

Top-Tier University Development Scheme for Research and Control of Infectious Disease

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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