The Utility of Iron Chelators in the Management of Inflammatory Disorders-Reference-Cited by-同舟云学术

The Utility of Iron Chelators in the Management of Inflammatory Disorders

Published:2015 Issue: Volume:2015 Page:1-12
ISSN:0962-9351
Container-title:Mediators of Inflammation
language:en
Short-container-title:Mediators of Inflammation

Author:

Lehmann C.¹²³,Islam S.¹³⁴,Jarosch S.¹,Zhou J.¹²,Hoskin D.²⁵,Greenshields A.⁵,Al-Banna N.¹,Sharawy N.¹⁶,Sczcesniak A.³,Kelly M.¹³,Wafa K.¹,Cheliak W.⁷,Holbein B.⁷

Affiliation:

1. Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5

2. Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 1X5

3. Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5

4. Department of Pharmacy, East West University, Plot No. A/2, Jahurul Islam City, Aftabnagar, Dhaka 1219, Bangladesh

5. Department of Pathology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5

6. Department of Physiology, Faculty of Medicine, Cairo University, 1 Al-Saray St., Cairo 11559, Egypt

7. Chelation Partners Inc., 1411 Oxford St., Halifax, NS, Canada B3H 3Z1

Abstract

Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. Under pathological conditions with reduced or increased baseline iron levels different consequences regarding protection or susceptibility to inflammation have to be considered. Given the role of iron in development of inflammatory diseases, pharmaceutical agents targeting this pathway promise to improve the clinical outcome. The objective of this review is to highlight the mechanisms of iron regulation and iron chelation, and to demonstrate the potential impact of this strategy in the management of several acute and chronic inflammatory diseases, including cancer.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Link

http://downloads.hindawi.com/journals/mi/2015/516740.pdf

Reference134 articles.

1. Iron Homeostasis and the Inflammatory Response

2. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

3. The Anemia Associated With Chronic Infection

4. Intestinal iron absorption

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