Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation-Reference-Cited by-同舟云学术

Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation

Published:2018-08-12 Issue: Volume:2018 Page:1-7
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Pinacchio Claudia¹^ORCID,Scheri Giuseppe Corano¹,Statzu Maura²,Santinelli Letizia²^ORCID,Ceccarelli Giancarlo¹,Innocenti Giuseppe Pietro¹^ORCID,Vullo Vincenzo¹,Antonelli Guido²³,Brenchley Jason M.⁴,d’Ettorre Gabriella¹,Scagnolari Carolina²³

Affiliation:

1. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy

2. Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina 28, 00185 Rome, Italy

3. Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Viale Regina Elena 291, 00161 Rome, Italy

4. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA

Abstract

Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2018/1738676.pdf

Reference22 articles.

1. HIV-1 and interferons: who's interfering with whom?

2. Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers

3. Antiviral activity of the interferon α family: biological and pharmacological aspects of the treatment of chronic hepatitis C