Does Rubella Immunity Predict Measles Immunity? A Serosurvey of Pregnant Women

Abstract

Background. This study was undertaken to determine whether rubella immunity infers measles immunity in pregnant women.Methods. Stored serum samples were obtained from the Iowa State Hygienic Laboratory for evaluation of rubella and measles immunities with IgG enzyme-linked immunosorbent assay.Results. Nine hundred serum samples were obtained for testing. The average age of the women at the time of antepartum serum collection was28(range,14to44) years. Measles and rubella immunity were88%and98%, respectively; there was no effect of immunity status by age identified. Eighty eight percent of those with rubella immunity were also measles immune. There was no association between paired rubella and measles immunity identified,P<.0001.Discussion. Known rubella immunity did not infer measles immunity in our population. Thus, we recommend that pregnant women exposed to measles be tested and appropriately treated if they are found to be nonimmune.