A 64-Year-Old Woman with Chest Pain, Limb Weakness, and Endometrial Cancer

Author:

Ponthus Simon1ORCID,Kherad Omar1,Petriccioli Nicole1,Lobrinus Johannes Alexander2,Guerne Pierre-André A.3

Affiliation:

1. Internal Medicine Department, Hôpital de la Tour, Geneva, Switzerland

2. Department of Pathology, Geneva University Hospitals, Geneva, Switzerland

3. Department of Rheumatology, Geneva University Hospitals, Geneva, Switzerland

Abstract

Necrotizing autoimmune myopathy (NAM) is a rare subgroup of idiopathic inflammatory myopathies (IIM). This pathology usually affects proximal limb muscles and in some cases the myocardium. Patients usually display proximal limb weakness. Muscular biopsy is required to confirm the diagnosis. We report the case of a 64-year-old woman with an atypical first presentation of NAM, manifested by chest pain in the context of metastatic endometrial cancer. The diagnosis of NAM was however made when she returned a second time with proximal limb weakness. A treatment with prednisone was then initiated, to which rituximab was rapidly associated, beside a specific chemotherapy.

Publisher

Hindawi Limited

Subject

General Agricultural and Biological Sciences

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