Effects of Valsartan on LN, FN, MDA, Renal Tissue Fibrosis, and Inflammatory Infiltration in DN Rats-Reference-Cited by-同舟云学术

Effects of Valsartan on LN, FN, MDA, Renal Tissue Fibrosis, and Inflammatory Infiltration in DN Rats

Published:2022-08-04 Issue: Volume:2022 Page:1-8
ISSN:1555-4317
Container-title:Contrast Media & Molecular Imaging
language:en
Short-container-title:Contrast Media & Molecular Imaging

Author:

Qin Yongting¹^ORCID,Li Gugangzhi¹,Chen Juan²,Qin Shuangli¹,Wang Shizhen¹,Chen Shanshan¹

Affiliation:

1. Department of Basic Medica, Jiangsu College of Nursing, Huaian 223005, China

2. Department of Endocrinology, Huai’an First People’s Hospital, Huaian 223300, China

Abstract

The effects of valsartan on laminin (LN), fibronectin (FN), malondialdehyde (MDA), renal tissue fibrosis, and inflammatory infiltration in diabetic nephropathy (DN) rats are explored. A total of 42 SPF male Sprague D (SD) rats are selected and randomly divided into normal set, model set, valsartan low-dose and high-dose sets, and metformin set with 7 rats in each set. The kidney tissue of all rats is collected after administration. The standard of protein mRNA in kidney tissues is detected by real-time fluorescence quantitative polymerase chain reaction (PCR) method, and the protein standard in kidney tissues is detected by western blot. The experimental results show that the application of valsartan to DN rats can effectively relieve the morphology of the rat kidney tissue, enhance the protein expression in the kidney tissue of the DN rats, and reduce the fibrosis and inflammatory infiltration of the kidney tissue.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Radiology, Nuclear Medicine and imaging

Link

http://downloads.hindawi.com/journals/cmmi/2022/6473393.pdf

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Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Retracted: Effects of Valsartan on LN, FN, MDA, Renal Tissue Fibrosis, and Inflammatory Infiltration in DN Rats;Contrast Media & Molecular Imaging;2023-07-26

2. Two-Drug Combinations Therapy of Different Doses of Valsartan Existing Diverse Significance for Hypertensive Patients;Reviews in Cardiovascular Medicine;2023-06-29