1. Department of Medicine, University of Toronto, Toronto, Ontario, Canada
2. Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
3. Trauma, Emergency and Critical Care Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
4. Department of Pharmacy, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
5. Division of Infectious Diseases, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada