Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives-Reference-Cited by-同舟云学术

Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

Published:2015 Issue: Volume:2015 Page:1-6
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

El Fal Mohammed¹,Ramli Youssef²,Zerzouf Abdelfettah³,Talbaoui Ahmed⁴,Bakri Youssef⁴,Essassi El Mokhtar¹

Affiliation:

1. Laboratoire de Chimie Organique Hétérocyclique URAC 21, Faculté des Sciences, Université Mohammed V, Rabat, Morocco

2. Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170 Rabat, Morocco

3. Laboratoire de Physico-Chimie des Matériaux Inorganiques et Organiques (LPCMIO), ENS, Rabat, Morocco

4. Laboratoire de Biochimie et Immunologie, Faculté des Sciences, Université Mohammed V, Rabat, Morocco

Abstract

New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR,13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains:Staphylococcus aureus,Enterococcus faecalis,Escherichia coli, andPseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL againstStaphylococcus aureusandStreptococcus fasciens.

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2015/982404.pdf

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