Design, Synthesis, andIn VitroAntiplatelet Aggregation Activities of Ferulic Acid Derivatives-Reference-Cited by-同舟云学术

Design, Synthesis, andIn VitroAntiplatelet Aggregation Activities of Ferulic Acid Derivatives

Published:2015 Issue: Volume:2015 Page:1-7
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Zhang Peng-Xuan¹,Lin Hang¹,Qu Cheng¹,Tang Yu-Ping¹,Li Nian-Guang¹,Kai Jun¹,Shang Guanxiong¹,Li Baoquan¹,Zhang Li¹,Yan Hui¹,Liu Pei¹,Duan Jin-Ao¹

Affiliation:

1. Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, China

Abstract

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. Thein vitroantiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound7fhad potent antiplatelet aggregation activity with its IC5027.6 μmol/L, and7fcan be regarded as a novel potent antiplatelet aggregation candidate.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2015/376527.pdf

Reference39 articles.

1. Foundation and sites of action of antithrombotic agents

2. Effects of ultrasound energy on thrombi in vitro

3. Enhancement of thrombolysis by ultrasound