Meta-Analysis on the Anesthetic Effects of Remifentanil plus Dexmedetomidine versus Remifentanil Alone in Cardiac Surgery

Abstract

In this study, we performed a meta-analysis to investigate the anesthesia effects of remifentanil plus dexmedetomidine versus remifentanil alone in cardiac surgery. Literature search was performed on PubMed, Web of Science, Embase, China Knowledge Infrastructure, Wanfang Data, and other databases for relevant literature published in English or Chinese before October 2021. A total of 17 studies, consisting of 1350 patients, were included in this study. Of these, 10 studies showed that remifentanil plus dexmedetomidine had a good anesthesia effect in cardiac surgery ( $\text{OR}=3.61$ , 95% CI: 1.73, 7.52, $P<0.001$ ), and 8 studies showed that the Ramsay score test of anesthesia ( $\text{SMD}=0.88$ ; 95% CI: -0.77, 2.53; $P<0.001$ ) in the experimental group was better than that in the control group. In addition, changes in the hemodynamic heart rate ( $\text{SMD}=-0.74$ ; 95% CI: -1.41, -0.07; $P<0.001$ ) and mean arterial pressure ( $\text{SMD}=-0.18$ ; 95% CI: -0.72, 0.36; $P<0.001$ ) of the two groups of anesthesia were counted in 17 studies, which also showed that the anesthesia effect of remifentanil plus dexmedetomidine was good. Thus, remifentanil plus dexmedetomidine may be a more promising option for cardiac surgery anesthesia than remifentanil alone.