Interfacial Interactions and Nanostructure Changes in DPPG/HD Monolayer at the Air/Water Interface

Author:

Zhu Huaze12,Sun Runguang1,Zhang Tao2,Hao Changchun1,Zhang Pengli12,Wang Juan1,Li Shaorong2

Affiliation:

1. College of Physics and Information Technology, Shaanxi Normal University, Chang-an Street No. 199, Xi’an 710062, China

2. College of Science, Xi’an University of Science and Technology, Yanta Road No. 58, Xi’an 710054, China

Abstract

Lung surfactant (LS) plays a crucial role in regulating surface tension during normal respiration cycles by decreasing the work associated with lung expansion and therefore decreases the metabolic energy consumed. Monolayer surfactant films composed of a mixture of phospholipids and spreading additives are of optional utility for applications in lung surfactant-based therapies. A simple, minimal model of such a lung surfactant system, composed of 1,2-dipalmitoyl-sn-glycero-3-[phosphor-rac-(1-gylcerol)] (DPPG) and hexadecanol (HD), was prepared, and the surface pressure-area (π-A) isotherms and nanostructure characteristics of the binary mixture were investigated at the air/water interface using a combination of Langmuir-Blodgett (LB) and atomic force microscopy (AFM) techniques. Based on the regular solution theory, the miscibility and stability of the two components in the monolayer were analyzed in terms of compression modulus (Cs-1) , excess Gibbs free energy (ΔGexcπ) , activity coefficients (γ), and interaction parameter (ξ). The results of this paper provide valuable insight into basic thermodynamics and nanostructure of mixed DPPG/HD monolayers; it is helpful to understand the thermodynamic behavior of HD as spreading additive in LS monolayer with a view toward characterizing potential improvements to LS performance brought about by addition of HD to lung phospholipids.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Materials Science

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