Wild Mushrooms in Nepal: Some Potential Candidates as Antioxidant and ACE-Inhibition Sources

Author:

Hai Bang Tran12,Suhara Hiroto3,Doi Katsumi1,Ishikawa Hiroya4,Fukami Katsuya5,Parajuli Gopal Prasad6,Katakura Yoshinori1,Yamashita Shuntaro7,Watanabe Kazuo6,Adhikari Mahesh Kumar8,Manandhar Hira Kaji6,Kondo Ryuichiro1,Shimizu Kuniyoshi1

Affiliation:

1. Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan

2. Department of Chemistry, Hue College of Sciences, Hue University, 77 Nguyen Hue, Hue, Vietnam

3. Miyazaki Prefectural Wood Utilization Research Center, Miyazaki 885-0037, Japan

4. International College of Arts and Sciences, Fukuoka Women's University, Fukuoka 813-8529, Japan

5. Material Management Center, Kyushu University, Fukuoka 812-8581, Japan

6. Plant Pathology Division, Nepal Agriculture Research Council, Khumaltar, Lalitpur, Nepal, P.O. Box. 3605, Kathmandu, Nepal

7. Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 812-8581, Japan

8. 254 Adhikari Niwas, Alka Basti, Lainchour, P.O. Box 21758, 29, Kathmandu, Nepal

Abstract

Twenty-nine mushrooms collected in the mountainous areas of Nepal were analyzed for antioxidant activity by different methods, including Folin-Ciocalteu, ORAC, ABTS, and DPPH assays. Intracellular H2O2-scavenging activity was also performed on HaCaT cells. The results showed that phenolic compounds are the main antioxidant of the mushrooms. Among studied samples,Inonotus andersonii, andPhellinus gilvusexhibited very high antioxidant activity with the phenolic contents up to 310.8 and 258.7 mg GAE/g extracts, respectively. The H2O2-scavenging assay on cells also revealed the potential of these mushrooms in the prevention of oxidative stress. In term of ACE-inhibition, results showed thatPhlebia tremellosawould be a novel and promising candidate for antihypertensive studies. This mushroom exhibited even higherin vitroACE-inhibition activity thanGanoderma lingzhi, with the IC50values of the two mushrooms being 32 μg/mL and 2 μg/mL, respectively. This is the first time biological activities of mushrooms collected in Nepal were reported. Information from this study should be a valuable reference for future studies on antioxidant and ACE-inhibitory activities of mushrooms.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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